Differin Cream is proposed for the cutaneous treatment of mild to moderate acne vulgaris where comedones, papules and pustules predominate.Differin Cream is best suited for use on dry and fair skin. Acne of the face, chest or back is appropriate for treatment.This medication is used to treat acne. it may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. adapalene belongs to a class of medications called retinoids. it works by affecting the growth of cells and decreasing swelling and inflammation.